Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries-Reference-Cited by-同舟云学术

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Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries

Published:2024 Issue:59 Volume:60 Page:7638-7641
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Huihong¹²,Chen Teng²,Fan Xiaohong¹,Li Yangfeng²^ORCID,Fang Wei¹,Zhang Gong²^ORCID,Li Yizhou²^ORCID

Affiliation:

1. Pharmaceutical Department, Chongqing University Three Gorges Hospital, Chongqing University, 404100 Chongqing, P. R. China

2. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, China

Abstract

DNA-compatible diversity-oriented synthesis of nitrogen-containing heterocycles via the in situ conversion of primary amines into versatile isothiocyanates intermediates.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02547D

Reference33 articles.

1. DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges

2. Impact of library input on the hit discovery rate in DNA-encoded chemical library selections

3. Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries

4. Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis

5. Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

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