Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry-Reference-Cited by-同舟云学术

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

Published:2020-06-25 Issue:14 Volume:63 Page:7840-7856
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cuozzo John W.¹^ORCID,Clark Matthew A.¹,Keefe Anthony D.¹,Kohlmann Anna¹,Mulvihill Mark²,Ni Haihong³,Renzetti Louis M.²,Resnicow Daniel I.¹,Ruebsam Frank³,Sigel Eric A.¹,Thomson Heather A.¹,Wang Ce³,Xie Zhifeng³,Zhang Ying¹

Affiliation:

1. X-Chem, Inc., 100 Beaver Street, Suite 101, Waltham, Massachusetts 02543, United States

2. X-Rx, Inc., 430 East 29th Street, Suite 1060, New York, New York 10016, United States

3. BioDuro, LLC, Building E, No. 29 Life Science Park Road, Changping District, Beijing 102206, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00688

Reference23 articles.

1. Autotaxin--an LPA producing enzyme with diverse functions

2. Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1

3. Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

4. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation

5. Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

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