Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells-Reference-Cited by-同舟云学术

Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells

Published:2022 Issue:2 Volume:10 Page:514-523
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Kim Hye Jin¹,Park Jong Min¹,Lee Sujin¹,Cho Hui Bang¹,Park Ji-In¹,Kim Jae-Hwan²,Park Ji Sun¹,Park Keun-Hong¹^ORCID

Affiliation:

1. Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea

2. Molecular Genetics, Department of Biomedical Science, College of Life Science, CHA University, 605, CHA Biocomplex, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea

Abstract

Effective knockdown of the RUNX2 gene by CRISPR-Cas9-based nanoparticles (CASP-NPs) is even more effective in chondrogenic differentiation.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01716K

Reference32 articles.

1. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector