Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography-Reference-Cited by-同舟云学术

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Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Published:2014 Issue:4 Volume:5 Page:540-546
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Guetzoyan Lucie¹²³⁴,Ingham Richard J.¹²³⁴,Nikbin Nikzad¹²³⁴,Rossignol Julien¹²³⁴,Wolling Michael¹²³⁴,Baumert Mark⁵⁶⁷,Burgess-Brown Nicola A.⁸⁹¹⁰¹¹,Strain-Damerell Claire M.⁸⁹¹⁰¹¹,Shrestha Leela⁸⁹¹⁰¹¹,Brennan Paul E.⁸⁹¹⁰¹¹,Fedorov Oleg⁸⁹¹⁰¹¹,Knapp Stefan⁸⁹¹⁰¹¹,Ley Steven V.¹²³⁴

Affiliation:

1. Innovative Technology Centre

2. Department of Chemistry

3. University of Cambridge

4. , UK

5. Advion Ltd

6. Harlow Enterprise Hub

7. Harlow, UK

8. Structural Genomics Consortium and Target Discovery Institute

9. Nuffield Department of Medicine

10. University of Oxford

11. Oxford, UK

Abstract

Novel technologies were developed and used for the synthesis and evaluation of new triazolopyridazine BRD9 inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00007B

Reference30 articles.

1. Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

2. Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

3. Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

4. Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies

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