Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice

Author:

Chen Jinfen1,Xu Lieqiang1,Jiang Linyun2,Wu Yulin1,Wei Long3,Wu Xiaoli4,Xiao Shihong3,Liu Yuhong1,Gao Changjun35,Cai Jian35,Su Ziren16ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China

2. The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China

3. Guangdong Academy of Forestry, Guangzhou, 510520, People's Republic of China

4. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China

5. Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou, 510520, People's Republic of China

6. Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Medicine, Dongguan, 523808, People's Republic of China

Abstract

Sonneratia apetala seed oil alleviated hyperuricemia by regulating xanthine oxidase activity and expressions of renal transporters, and mitigated hyperuricemia-induced renal injury by suppressing oxidative stress and inflammation.

Funder

Special Project for Research and Development in Key areas of Guangdong Province

Department of Education of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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