Hydrocarbon constrained peptides – understanding preorganisation and binding affinity-Reference-Cited by-同舟云学术

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Hydrocarbon constrained peptides – understanding preorganisation and binding affinity

Published:2016 Issue:6 Volume:7 Page:3694-3702
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Miles Jennifer A.¹²³⁴⁵^ORCID,Yeo David J.¹²³⁴⁵,Rowell Philip¹²³⁴⁶,Rodriguez-Marin Silvia¹²³⁴⁵,Pask Christopher M.¹²³⁴,Warriner Stuart L.¹²³⁴⁵^ORCID,Edwards Thomas A.⁵²³⁴⁶,Wilson Andrew J.¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry

2. University of Leeds

3. Leeds LS2 9JT

4. UK

5. Astbury Centre for Structural Molecular Biology

6. School of Molecular and Cellular Biology

Abstract

Biophysical studies on hydrocarbon constrained peptides reveal induced fit binding and enthalpy–entropy compensation on target protein recognition.

Funder

Wellcome Trust

European Research Council

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04048E

Reference57 articles.

1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2. Inhibition of α-helix-mediated protein–protein interactions using designed molecules

3. Towards understanding cell penetration by stapled peptides

4. Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

5. Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies

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