Peptide macrocyclisation <i>via</i> intramolecular interception of visible-light-mediated desulfurisation-Reference-Cited by-同舟云学术

Peptide macrocyclisation via intramolecular interception of visible-light-mediated desulfurisation

Published:2024 Issue:25 Volume:15 Page:9612-9619
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Smith Frances R.¹,Meehan Declan¹,Griffiths Rhys C.¹,Knowles Harriet J.¹,Zhang Peiyu²,Williams Huw E. L.³^ORCID,Wilson Andrew J.²⁴^ORCID,Mitchell Nicholas J.¹^ORCID

Affiliation:

1. School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

2. School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK

3. Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

4. School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

Abstract

Herein, we report a peptide cyclisation strategy via intramolecular interception of cysteine desulfurisation. This method enables the cyclisation of unprotected peptides in aqueous solution via the installation of a hydrocarbon linkage.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Leverhulme Trust

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05865D

Reference72 articles.

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2. Visible-Light-Mediated Peptide Macrocyclization via Intermolecular Interception of Desulfurization;Synfacts;2024-07-25