Engineered coiled-coil HIF1α protein domain mimic

Author:

Britton Dustin1,Katsara Olga2,Mishkit Orin34,Wang Andrew156,Pandya Neelam34,Liu Chengliang1,Mao Heather134,Legocki Jakub1,Jia Sihan1,Xiao Yingxin1,Aristizabal Orlando34,Paul Deven1,Deng Yan7,Schneider Robert28,Wadghiri Youssef Z.34,Montclare Jin Kim1391011ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA

2. Department of Microbiology, New York University School of Medicine, New York, New York, 10016, USA

3. Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA

4. Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA

5. Department of Biomedical Engineering, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA

6. College of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA

7. Microscopy Laboratory, New York University Langone Health, New York, NY, 10016, USA

8. Department of Radiation Oncology, New York University School of Medicine, New York, New York, 10016, USA

9. Department of Chemistry, New York University, New York, New York, 10012, USA

10. Department of Biomaterials, New York University College of Dentistry, New York, New York, 10010, USA

11. Department of Biomedical Engineering, New York University, New York, NY, 11201, USA

Abstract

Multivalent assembled proteins (MAPs) as protein domain mimics (PDMs) of HIF1α allows for improved tumor targeting.

Funder

National Institutes of Health

Division of Materials Research

Publisher

Royal Society of Chemistry (RSC)

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