Discrepancy between thermodynamic and kinetic stabilities of thetert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying-Reference-Cited by-同舟云学术

Discrepancy between thermodynamic and kinetic stabilities of thetert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

Published:2019 Issue:29 Volume:55 Page:4262-4265
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ogienko A. G.¹²³⁴²^ORCID,Stoporev A. S.¹²³⁴²^ORCID,Ogienko A. A.¹²³⁵²^ORCID,Mel’gunov M. S.⁴²³⁶²^ORCID,Adamova T. P.¹²³^ORCID,Yunoshev A. S.⁴²³⁷²,Manakov A. Yu.¹²³⁴²^ORCID,Boldyreva E. V.⁴²³⁶²^ORCID

Affiliation:

1. Nikolaev Institute of Inorganic Chemistry SB RAS

2. 630090 Novosibirsk

3. Russia

4. Novosibirsk State University

5. Institute of Molecular and Cellular Biology SB RAS

6. Boreskov Institute of Catalysis SB RAS

7. Lavrentiev Institute of Hydrodynamics SB RAS

Abstract

The substitution of sublimed “H1 + Ih” for “H2 + Ih” leads to both a reduction of primary drying time and a significant increase in specific surface area of the trehalose freeze-dried cakes.

Funder

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC00397E

Reference35 articles.

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3. Drug-delivery Products and the Zydis Fast-dissolving Dosage Form

4. Freeze-Drying of tert-Butyl Alcohol/Water Cosolvent Systems: Effects of Formulation and Process Variables on Residual Solvents

5. D. L. Teagarden , W.Wang and D. S.Baker , Freeze Drying/Lyophilization of Pharmaceutical and Biological Products , Informa Healthcare , London , 3rd edn, 2010 , pp. 254–287

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