t-Butanol Enables Dual Functionality of Mannitol: A Cryoprotectant in Frozen Systems and Bulking Agent in Freeze-Dried Formulations
Author:
Affiliation:
1. Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 308 Harvard Street, Minneapolis, Minnesota 55455, United States
Funder
University of Minnesota
Dane O. Kildsig Center for Pharmaceutical Processing Research
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00492
Reference36 articles.
1. Current Perspectives on Stability of Protein Drug Products during Formulation, Fill and Finish Operations
2. Mechanisms by which crystalline mannitol improves the reconstitution time of high concentration lyophilized protein formulations
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