Ferulic acid protects against methotrexate nephrotoxicityviaactivation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis-Reference-Cited by-同舟云学术

Ferulic acid protects against methotrexate nephrotoxicityviaactivation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis

Published:2019 Issue:8 Volume:10 Page:4593-4607
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Mahmoud Ayman M.¹²³⁴⁵^ORCID,Hussein Omnia E.¹²³⁴⁵,Abd El-Twab Sanaa M.¹²³⁴⁵,Hozayen Walaa G.⁶⁷³⁴⁵

Affiliation:

1. Physiology Division

2. Department of Zoology

3. Faculty of Science

4. Beni-Suef University

5. Egypt

6. Biochemistry Division

7. Chemistry Department

Abstract

Ferulic acid prevents methotrexate-induced acute kidney injury by suppressing ROS/NF-κB/NLRP3 inflammasome axis, and activating PPARγ and Nrf2/ARE/HO-1 signaling.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C9FO00114J

Reference85 articles.

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4. Renal Vulnerability to Drug Toxicity

5. Methotrexate in systemic lupus erythematosus: a systematic review of its efficacy

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