Synthetic spirocyclic endoperoxides: new antimalarial scaffolds-Reference-Cited by-同舟云学术

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Published:2015 Issue:2 Volume:6 Page:357-362
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Brindisi Margherita¹²³⁴⁵,Gemma Sandra¹²³⁴⁵,Kunjir Sanil¹²³⁴⁵,Di Cerbo Luisa¹²³⁴⁵,Brogi Simone¹²³⁴⁵,Parapini Silvia¹²³⁴⁶,D'Alessandro Sarah¹²³⁴⁶,Taramelli Donatella¹²³⁴⁶,Habluetzel Annette⁶⁷⁸⁴⁹,Tapanelli Sofia⁶⁷⁸⁴⁹,Lamponi Stefania¹²³⁴⁵,Novellino Ettore¹²³⁴¹⁰,Campiani Giuseppe¹²³⁴⁵,Butini Stefania¹²³⁴⁵

Affiliation:

1. European Research Centre for Drug Discovery and Development (NatSynDrug)

2. University of Siena

3. Siena

4. Italy

5. Dip. di Biotecnologie

6. Centro Interuniversitario di Ricerche sulla Malaria (CIRM)

7. University of Perugia

8. Perugia

9. School of Pharmacy

10. Dip. di Farmacia

Abstract

Design, synthesis and molecular docking calculation studies led to the identification of novel spirocyclic peroxides with in vitro and in vivo antimalarial activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00454J

Reference23 articles.

1. World Health Organization , World Malaria Report , 2013 , Geneva

2. Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis

3. http://www.who.int/malaria/publications/atoz/9789241500838/en/ , access date: 28/07/2014

4. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

5. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

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