E. coli cells expressing the Baeyer–Villiger monooxygenase ‘MO14’ (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor-Reference-Cited by-同舟云学术

E. coli cells expressing the Baeyer–Villiger monooxygenase ‘MO14’ (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

Published:2015 Issue:6 Volume:13 Page:1897-1903
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Summers Benjamin D.¹²³⁴⁵,Omar Muhiadin¹²³⁴⁵,Ronson Thomas O.¹²³⁴⁵,Cartwright Jared⁶⁷⁸⁹,Lloyd Michael¹⁰¹¹¹²⁹,Grogan Gideon¹²³⁴⁵

Affiliation:

1. B.D. Summers

2. M. Omar

3. T. Ronson

4. Dr G. Grogan

5. York Structural Biology Laboratory

6. Technology Facility

7. Department of Biology University of York

8. York YO10 5DD

9. UK

10. Chirotech Technology Ltd

11. Dr Reddy's Laboratories (EU) Ltd

12. Cambridge

Abstract

(1S,5R)-2-Oxalactone of >99% ee and (1S,5R)-ketone of 96% ee are produced after approximately 14 h at a temperature of 16 °C.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01441C

Reference30 articles.

1. Baeyer–Villiger monooxygenases: recent advances and future challenges

2. Baeyer−Villiger Monooxygenases: More Than Just Green Chemistry

3. Discovery, application and protein engineering of Baeyer–Villiger monooxygenases for organic synthesis

4. Protein Engineering of Stereoselective Baeyer-Villiger Monooxygenases

5. Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

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