Affiliation:
1. Curnow Consultancies Ltd., Trewithen House, Helston TR13 9PQ, Cornwall, UK
Abstract
The role of cofactor recycling in determining the efficiency of artificial biocatalytic cascades has become paramount in recent years. Closed-loop cofactor recycling, which initially emerged in the 1990s, has made a valuable contribution to the development of this aspect of biotechnology. However, the evolution of redox-neutral closed-loop cofactor recycling has a longer history that has been integrally linked to the enzymology of oxy-functionalised bicyclo[3.2.0]carbocyclic molecule metabolism throughout. This review traces that relevant history from the mid-1960s to current times.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference314 articles.
1. A unified strategy to prostaglandins: Chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF2α, fluprostanol, and travoprot guided by biocatalytic retrosynthesis;Zhu;Chem. Sci.,2021
2. Biotransformation of endo-bicyclo[2.2.1]heptanols and endo-bicyclo[ 3.2.0]hept-2-en-6-ols into corresponding lactones;Willetts;J. Chem. Soc. Perkin Trans. I,1991
3. Discovery and development of new β-lactam antibiotics;Brown;Pure Appl. Chem.,1987
4. Crowfoot, D., Bunn, C., Low, B., and Turner-Jones, A. (1949). Chemistry of Penicillin, Princeton University Press.
5. SQ 27,860. A simple carbapenen produced by species of Serratia and Erwinia;Parker;J. Antibiot.,1982