A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF2α, fluprostenol, and travoprost guided by biocatalytic retrosynthesis-Reference-Cited by-同舟云学术

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF2α, fluprostenol, and travoprost guided by biocatalytic retrosynthesis

Published:2021 Issue:30 Volume:12 Page:10362-10370
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhu Kejie¹²³⁴⁵,Jiang Meifen¹²³⁴⁵,Ye Baijun¹²³⁴⁵^ORCID,Zhang Guo-Tai⁶⁷⁸⁹⁵,Li Weijian⁶⁷⁸⁹⁵,Tang Pei⁶⁷⁸⁹⁵,Huang Zedu¹²³⁴⁵^ORCID,Chen Fener¹²³⁴⁵^ORCID

Affiliation:

1. Engineering Center of Catalysis and Synthesis for Chiral Molecules

2. Department of Chemistry

3. Fudan University

4. Shanghai

5. P. R. China

6. Sichuan Research Center for Drug Precision Industrial Technology

7. West China School of Pharmacy

8. Sichuan University

9. Chengdu

Abstract

We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and a copper(ii)-catalyzed regioselective p-phenylbenzoylation.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03237B

Reference86 articles.

1. Synthesis of therapeutically useful prostaglandin and prostacyclin analogs

2. Recent Developments in the Synthesis of Prostaglandins and Analogues