Formal oxygen atom insertion as a skeletal-editing step: rapid access natural-product-inspired bispiro[oxindole-oxazinane] hybrids-Reference-Cited by-同舟云学术

Formal oxygen atom insertion as a skeletal-editing step: rapid access natural-product-inspired bispiro[oxindole-oxazinane] hybrids

Published:2023 Issue:13 Volume:10 Page:3307-3312
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Shi Qing-Hui¹,Wang Yu-Heng¹,Chen Zi-Yue¹,Wang Xi-Rui¹,Zhang Wen-Hui²,Tian Fang-Li¹,Peng Li-Jun¹,Zhou Ying²,Liu Xiong-Li¹^ORCID

Affiliation:

1. National & Local Joint Engineering Research Center for the Exploition of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, Guizhou, China

2. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China

Abstract

An unprecedented example of skeletal editing of pyrrolidines to 1,2-oxazinanes expands the applicability scope of “single-atom” skeletal-editing technologies.

Funder

Data Center of Management Science, National Natural Science Foundation of China - Peking University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00595J

Reference58 articles.

1. Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

2. The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

3. Recent Advances in Scaffold Hopping