Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions-Reference-Cited by-同舟云学术

Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al₂O₃ surface under ball-milling conditions

Published:2022 Issue:11 Volume:12 Page:6396-6402
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Hernandez R. Rafael A.¹^ORCID,Burchell-Reyes Kelly¹,Braga Arthur P. C. A.¹,Lopez Jennifer Keough¹,Forgione Pat¹²^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Concordia University, 7141 rue Sherbrooke O., Montréal, QC, Canada H4B 1R6

2. Centre for Green Chemistry and Catalysis, McGill University, 801 rue Sherbrooke O., Montréal, QC, Canada H3A 0B8

Abstract

A practical and scalable mechanochemical 1,3-dipolar cycloaddition between hydroxyimidoyl chlorides and terminal alkynes catalyzed by Cu/Al2O3 allows a quick access to 3,5-isoxazole derivatives.

Funder

Natural Sciences and Engineering Research Council of Canada

Fonds de recherche du Québec – Nature et technologies

Centre in Green Chemistry and Catalysis

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08443G

Reference69 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals