Copper Nitrate‐Mediated Selective Bond Cleavage of Alkynes: Diverse Synthesis of Isoxazoles<sup>†</sup>-Reference-Cited by-同舟云学术

Copper Nitrate‐Mediated Selective Bond Cleavage of Alkynes: Diverse Synthesis of Isoxazoles^†

Published:2023-09-08 Issue:23 Volume:41 Page:3299-3304
ISSN:1001-604X
Container-title:Chinese Journal of Chemistry
language:en
Short-container-title:Chin. J. Chem.

Author:

Liu Jianan¹,Zhou Kaijing¹,Sun Shaobo²,Gao Mingchun¹,Xu Bin¹³

Affiliation:

1. Department of Chemistry, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai Engineering Research Center of Organ Repair, Innovative Drug Research Center, School of Medicine Shanghai University Shanghai 200444 China

2. Qianweichang College Shanghai University Shanghai 200444 China

3. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai 200032 China

Abstract

Comprehensive SummaryAn unprecedented copper nitrate‐mediated bond cleavage of alkynes was developed for the modular synthesis of isoxazoles, where either C—S bond or C≡C triple bond was cleaved selectively. Substituents attached to the C≡C triple bonds could differentiate the chemical bonds cleavage and reaction pathways disparately. Various transformations of products illustrate promising applications of the given protocols.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cjoc.202300431

Reference42 articles.

1. Transition Metal‐Mediated Functionalization of Isoxazoles: A Review

2. Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

3. Step-by-Step Multifunctionalization of Isoxazoles Based On SEAr Reactions and C–H Direct Arylations

4. Synthesis of Natural ProductsviaIsoxazoles

5. Oxazole and isoxazole: From one-pot synthesis to medical applications

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