Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition-Reference-Cited by-同舟云学术

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Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Published:2014 Issue:12 Volume:5 Page:1834-1842
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sharp Phillip P.¹²³⁴⁵,Garnier Jean-Marc¹²³⁴⁵,Huang David C. S.¹²³⁴⁵,Burns Christopher J.¹²³⁴⁵

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research

2. Parkville

3. Australia

4. Department of Medical Biology

5. The University of Melbourne

Abstract

This work provides new insights into a range of acetyl-lysine mimetics as BET bromodomain inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00182F

Reference29 articles.

1. Bromodomains as therapeutic targets

2. Acetylation: a regulatory modification to rival phosphorylation?

3. Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

4. Lysine acetylation and the bromodomain: a new partnership for signaling

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