Ball milled glyco-graphene oxide conjugates markedly disrupted Pseudomonas aeruginosa biofilms

Author:

Tricomi Jacopo12,Cacaci Margherita34,Biagiotti Giacomo12,Caselli Lucrezia15,Niccoli Lorenzo67,Torelli Riccardo4,Gabbani Alessio8ORCID,Di Vito Maura3,Pineider Francesco8ORCID,Severi Mirko12ORCID,Sanguinetti Maurizio34ORCID,Menna Enzo910ORCID,Lelli Moreno67ORCID,Berti Debora15ORCID,Cicchi Stefano12ORCID,Bugli Francesca34,Richichi Barbara12ORCID

Affiliation:

1. Department of Chemistry ‘Ugo Schiff’, University of Firenze, Via della Lastruccia 13, 50019 Sesto Fiorentino, FI, Italy

2. Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Via G. Giusti, 9, 50121 Firenze, Italy

3. Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy

4. Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

5. Italian Center for Colloid and Surface Science (CSGI), Via della Lastruccia 3, Sesto Fiorentino, 50019, FI, Italy

6. Magnetic Resonance Centre (CERM), Department of Chemistry ‘Ugo Schiff’, University of Firenze, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, FI, Italy

7. Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine Paramagnetiche (CIRMMP), Via Luigi Sacconi 6, 50019 Sesto Fiorentino, FI, Italy

8. Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56132 Pisa, Italy

9. Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy

10. Centre for Mechanics of Biological Materials – CMBM, Via Marzolo 9, 35131 Padova, Italy

Abstract

Sugar headgroups have been grafted on the surface of graphene oxide (GO) by exploiting vibrational ball mills. The resulting glyco-GO conjugates significantly disrupt an already established P. aeruginosa biofilm.

Funder

Fondazione Umberto Veronesi

Università degli Studi di Padova

Fondazione Cassa di Risparmio di Firenze

Ministero della Salute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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