Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Author:

Biagiotti Giacomo1,Toniolo Gianluca12,Albino Martin13ORCID,Severi Mirko1ORCID,Andreozzi Patrizia1,Marelli Marcello4,Kokot Hana5,Tria Giancarlo1,Guerri Annalisa1ORCID,Sangregorio Claudio3,Rojo Javier6ORCID,Berti Debora17ORCID,Marradi Marco1ORCID,Cicchi Stefano12ORCID,Urbančič Iztok5,van Kooyk Yvette8,Chiodo Fabrizio89ORCID,Richichi Barbara12ORCID

Affiliation:

1. Department of Chemistry “Ugo Schiff”, University of Firenze, Via della Lastruccia 13, 50019 Sesto Fiorentino (Firenze), Italy

2. Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Firenze, Italy

3. ICCOM CNR via Madonna del Piano 10, 50019 Sesto Fiorentino (Firenze), Italy

4. Istituto di Scienze e Tecnologie Chimiche “Giulio Natta”, SCITEC-CNR, Via G. Fantoli 16/15, 20138, Milano, Italy

5. Laboratory of Biophysics, Condensed Matter Physics Department, Jožef Stefan Institute, Jamova c. 39, 1000, Ljubljana, Slovenia

6. Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Av. Américo Vespucio 49, Seville, 41092, Spain

7. Italian Center for Colloid and Surface Science (CSGI), 50019 Sesto Fiorentino (Firenze), Italy

8. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands

9. Institute of Biomolecular Chemistry, National Research Council (CNR), Pozzuoli, Napoli, Italy

Abstract

Hybrid cellulose nanocrystal-gold nanoparticles engineered with sugar headgroups is a functional glyconanomaterial that permits a direct visualization of the sugar headgroups-lectins interactions by cryo-transmission electron microscopy.

Funder

Fondazione Umberto Veronesi

Javna Agencija za Raziskovalno Dejavnost RS

Agencia Estatal de Investigación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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