Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB-Reference-Cited by-同舟云学术

Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Published:2023 Issue:19 Volume:14 Page:8893-8902
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Le Sayec Melanie¹,Carregosa Diogo²^ORCID,Khalifa Khadija³,de Lucia Chiara³⁴^ORCID,Aarsland Dag³⁴,Santos Cláudia N.²,Rodriguez-Mateos Ana¹^ORCID

Affiliation:

1. Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK

2. iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade Nova de Lisboa, Lisbon, Portugal

3. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway

4. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK

Abstract

We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia suing LC-MS and predicted their mechanism of transport across the BBB using in silico modelling.

Funder

Nasjonalforeningen for Folkehelsen

Evonik Operations

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO01913F