Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity via structure-based virtual screening-Reference-Cited by-同舟云学术

Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity via structure-based virtual screening

Published:2016 Issue:87 Volume:52 Page:12837-12840
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yang Chao¹²³⁴⁵,Wang Wanhe⁶⁷⁸⁵,Chen Linmin¹²³⁴⁵,Liang Jiaxin¹²³⁴⁵,Lin Sheng⁶⁷⁸⁵,Lee Ming-Yuen¹²³⁴⁵,Ma Dik-Lung⁶⁷⁸⁵,Leung Chung-Hang¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Macao

5. China

6. Department of Chemistry

7. Hong Kong Baptist University

8. Kowloon Tong

Abstract

We describe herein compound 1, which is similar to many known natural products, as an inhibitor of the VHL–HIF1α interaction via structure-based virtual screening.

Funder

Universidade de Macau

Health and Medical Research Fund

Hong Kong Baptist University

Science and Technology Development Fund

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC04938A

Reference40 articles.

1. The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

2. Targeting HIF-1 for cancer therapy

3. Cancer metabolism: Key players in metabolic reprogramming

4. Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion

5. Nonlinear partial differential equations and applications: Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

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