Targeting HIF-1 for cancer therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc1187.pdf
Reference107 articles.
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3. Wang, G. L., Jiang, B. -H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510–5514 (1995).
4. Harris, A. L. Hypoxia — a key regulatory factor in tumor growth. Nature Rev. Cancer 2, 38–46 (2001).
5. Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485–490 (1998).
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