Enzymatic dimerization in the biosynthetic pathway of microbial natural products-Reference-Cited by-同舟云学术

Enzymatic dimerization in the biosynthetic pathway of microbial natural products

Published:2021 Issue:8 Volume:38 Page:1469-1505
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Liu Jiawang¹,Liu Anan¹,Hu Youcai¹^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

Abstract

Cytochrome P450s, laccases, and intermolecular [4 + 2] cyclases, along with other enzymes were utilized to catalyze varied dimerization of matured natural products so as to create the structural diversity and complexity in microorganisms.

Funder

National Basic Research Program of China

Chinese Academy of Medical Sciences

Peking Union Medical College

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00063A

Reference217 articles.

1. Dimeric naphthylisoquinoline alkaloids: polyketide-derived axially chiral bioactive quateraryls