Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials-Reference-Cited by-同舟云学术

Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials

Published:2022 Issue:12 Volume:13 Page:1587-1604
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Toviwek Borvornwat¹²,Riley Jennifer³,Mutter Nicole³,Anderson Mark³,Webster Lauren³,Hallyburton Irene³,Gleeson Duangkamol⁴,Read Kevin D.³,Gleeson M. Paul¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand

2. Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 0900, Thailand

3. Drug Discovery Unit, Divison of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK

4. Applied Computational Chemistry Research Unit & Department of Chemistry, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand

Abstract

Twenty six new phenylurea substituted 2,4-diamino-pyrimidines active against Plasmodium falciparum (Pf) 3D7 are reported.

Funder

King Mongkut's Institute of Technology Ladkrabang

Royal Golden Jubilee (RGJ) Ph.D. Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00218C

Reference33 articles.