4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl-N-benzylpyrrolidine-3-carboxamides-Reference-Cited by-同舟云学术

4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl-N-benzylpyrrolidine-3-carboxamides

Published:2019-03-11 Issue:7 Volume:62 Page:3503-3512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meyers Marvin J.¹²^ORCID,Liu Jianguang³,Xu Jing³,Leng Fang³,Guan Jiantong³,Liu Zhijun³,McNitt Sarah A.¹²,Qin Limei⁴,Dai Linglin⁴,Ma Hongwei³,Adah Dickson⁴⁵,Zhao Siting⁴,Li Xiaofen⁴,Polino Alex J.⁶,Nasamu Armiyaw S.⁶,Goldberg Daniel E.⁶,Liu Xiaorong³,Lu Yongzhi³,Tu Zhengchao³,Chen Xiaoping⁴,Tortorella Micky D.³⁷

Affiliation:

1. Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States

2. Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, United States

3. Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

4. Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

5. University of Chinese Academy of Sciences, Beijing 100049, China

6. Departments of Medicine and Molecular Microbiology, Washington University in St. Louis, Saint Louis, Missouri 63110, United States

7. Legion/Lijien Pharmaceuticals, Guangzhou 510530, China

Funder

National Natural Science Foundation of China

National Institute of Allergy and Infectious Diseases

Ministry of Science and Technology of the People's Republic of China

Bureau of Science and Information Technology of Guangzhou

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01972

Reference31 articles.

1. World Malaria Report 2015; World Health Organization: Geneva, 2015.

2. World Malaria Report 2018; World Health Organization: Geneva, 2018.

3. Artemisinin resistance: current status and scenarios for containment

4. Artemisinin Resistance and Artemisinin-Based Combination Therapy Efficacy. Global Malaria Programme Status Report; World Health Organization: Geneva, 2018.

5. Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts

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