Advanced approaches of developing targeted covalent drugs-Reference-Cited by-同舟云学术

Advanced approaches of developing targeted covalent drugs

Published:2022 Issue:12 Volume:13 Page:1460-1475
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gai Conghao¹^ORCID,Harnor Suzannah J.²,Zhang Shihao¹,Cano Céline²,Zhuang Chunlin¹^ORCID,Zhao Qingjie¹

Affiliation:

1. Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, 200433, P. R. China

2. Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK

Abstract

This review highlights developing strategies of covalent drug discovery and successful applications to address challenges of designing effective covalent drugs.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00216G

Reference136 articles.

1. Covalent Inhibition in Drug Discovery

2. Covalent inhibitors: a rational approach to drug discovery

3. Potential Successes and Challenges of Targeted Cancer Therapies