Discovery of a 6-Aminobenzo[<i>b</i>]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities-Reference-Cited by-同舟云学术

Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities

Published:2024-08-12 Issue:9 Volume:7 Page:2755-2783
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Oleksak Patrik¹^ORCID,Rysanek David²^ORCID,Vancurova Marketa²,Vasicova Pavla²,Urbancokova Alexandra²,Novak Josef²,Maurencova Dominika²,Kashmel Pavel²,Houserova Jana²,Mikyskova Romana³,Novotny Ondrej³,Reinis Milan³^ORCID,Juda Pavel⁴^ORCID,Hons Miroslav⁴,Kroupova Jirina²^ORCID,Sedlak David⁵^ORCID,Sulimenko Tetyana⁶,Draber Pavel⁶,Chlubnova Marketa¹,Nepovimova Eugenie¹,Kuca Kamil¹^ORCID,Lisa Miroslav¹^ORCID,Andrys Rudolf¹,Kobrlova Tereza⁷,Soukup Ondrej⁷^ORCID,Janousek Jiri⁷,Prchal Lukas⁷,Bartek Jiri²⁸⁹,Musilek Kamil¹,Hodny Zdenek²

Affiliation:

1. Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, Hradec Kralove 500 03, Czech Republic

2. Laboratory of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic

3. Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic

4. BIOCEV, First Faculty of Medicine, Charles University, Prumyslova 595, Vestec 252 50, Czech Republic

5. CZ-OPENSCREEN, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic

6. Laboratory of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic

7. Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic

8. Danish Cancer Institute, Strandboulevarden 49, DK-2100 Copenhagen, Denmark

9. Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet, Stockholm 171 77, Sweden

Funder

European Commission

Agentura Pro Zdravotnick? V?zkum Cesk? Republiky

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Grantov? Agentura Cesk? Republiky

HORIZON EUROPE Marie Sklodowska-Curie Actions

Univerzita Hradec Kr?lov?

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00190

Reference74 articles.

1. Advanced approaches of developing targeted covalent drugs

2. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

3. Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development

4. Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization

5. The STAT3 inhibitor Stattic acts independently of STAT3 to decrease histone acetylation and modulate gene expression