Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions
Author:
Affiliation:
1. Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States
2. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00788
Reference328 articles.
1. Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology
2. Covalent Modifiers: An Orthogonal Approach to Drug Design
3. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
4. The resurgence of covalent drugs
5. Drug discovery for a new generation of covalent drugs
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