Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature-Reference-Cited by-同舟云学术

Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature

Published:2020 Issue:52 Volume:10 Page:31215-31232
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dehury Budheswar¹²³⁴⁵,Tang Ning¹²³⁴,Mehra Rukmankesh¹²³⁴^ORCID,Blundell Tom L.⁵⁶⁷,Kepp Kasper P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Technical University of Denmark

3. DK-2800 Kongens Lyngby

4. Denmark

5. Department of Biochemistry

6. University of Cambridge

7. UK

Abstract

Distinct membrane dynamics and conformations of C83- and Notch-bound γ-secretase may aid the development of Notch-sparing treatments of Alzheimer's disease.

Funder

Novo Nordisk Fonden

Det Frie Forskningsråd

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA04683C

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