New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents-Reference-Cited by-同舟云学术

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents

Published:2021 Issue:47 Volume:11 Page:29441-29452
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dawood Dina H.¹,Srour Aladdin M.²^ORCID,Saleh Dalia O.³,Huff Kelley J.⁴,Greco Francesca⁴,Osborn Helen M. I.⁴

Affiliation:

1. Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt

2. Department of Therapeutic Chemistry, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt

3. Pharmacology Department, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt

4. School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK

Abstract

Series of pyridine- (3a–o) and/or chromene- (4a–e) carbonitrile scaffolds have been designed, synthesized and evaluated for their bi-function activities, 3d was the only common derivative having combined vasodilation and anticancer properties.

Funder

National Research Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04758B

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