Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: <i>in silico</i> and <i>in vitro</i> studies-Reference-Cited by-同舟云学术

Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: in silico and in vitro studies

Published:2022 Issue:11 Volume:46 Page:5078-5090
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

El-Masry Rana M.¹,Al-Karmalawy Ahmed A.²^ORCID,Alnajjar Radwan³⁴,Mahmoud Sara H.⁵,Mostafa Ahmed⁵^ORCID,Kadry Hanan H.⁶,Abou-Seri Sahar M.⁷,Taher Azza T.⁶⁸

Affiliation:

1. Organic Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), October 6 city, Giza, Egypt

2. Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt

3. Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya

4. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

5. Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza 12622, Egypt

6. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

8. Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, October 6 University (O6U), October 6 City, Giza, Egypt

Abstract

The pharmacophoric features of the novel series of 1,3,4-oxadiazole–oxoindole conjugates (IVa–g) as potential anti-SARS-CoV-2 agents based on the reported Mpro inhibitor (Ia) are presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ04816C

Reference72 articles.

1. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

2. Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

3. An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China

4. Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

5. Design and synthesis of new 4-(2-nitrophenoxy)benzamide derivatives as potential antiviral agents: molecular modeling and in vitro antiviral screening

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