Preparation, in vitro and in vivo evaluation, and molecular dynamics (MD) simulation studies of novel F-18 labeled tumor imaging agents targeting focal adhesion kinase (FAK)-Reference-Cited by-同舟云学术

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Preparation, in vitro and in vivo evaluation, and molecular dynamics (MD) simulation studies of novel F-18 labeled tumor imaging agents targeting focal adhesion kinase (FAK)

Published:2018 Issue:19 Volume:8 Page:10333-10345
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Fang Yu¹²³⁴⁵^ORCID,Wang Dawei¹²³⁴⁵,Xu Xingyu¹²³⁴⁵,Dava Gila¹²³⁴⁵,Liu Jianping¹²³⁴⁵,Li Xiang¹²³⁴⁵,Xue Qianqian¹²³⁴⁵,Wang Huan¹²³⁴⁵,Zhang Jiangshan⁶⁷⁸⁵,Zhang Huabei¹²³⁴⁵

Affiliation:

1. Key Laboratory of Radiopharmaceuticals of Ministry of Education

2. College of Chemistry

3. Beijing Normal University

4. Beijing 100875

5. People's Republic of China

6. College of Chemistry and Chemical Engineering

7. Anyang Normal University

8. Anyang 455000

Abstract

Coronal micro-PET images of mice bearing S180 tumor at 30 min post-injection of [¹⁸F]2.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA00652K

Reference36 articles.

1. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

2. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

3. Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity

4. Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

5. Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

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