Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity

Published:2014-09-11 Issue:1 Volume:58 Page:237-251
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dao Pascal¹,Smith Nikaia¹,Tomkiewicz-Raulet Céline²,Yen-Pon Expédite¹,Camacho-Artacho Marta³,Lietha Daniel³,Herbeuval Jean-Phillipe¹,Coumoul Xavier²,Garbay Christiane¹,Chen Huixiong¹⁴

Affiliation:

1. Chemistry & Biology, Nucleo(s)tides & Immunology for Therapy (CBNIT), CNRS UMR8601, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale, 45 rue des Saints-Pères, 75270 Cedex 06 Paris, France

2. Toxicologie, Pharmacologie et Signalisation Cellulaire, INSERM, UMR S 1124, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale, 45 rue des Saints-Pères, 75270 Cedex 06 Paris, France

3. Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernández Almagro 3, Madrid 28029, Spain

4. School of Chemical Engineering and Light Industry, Guangdong University of Technology, no. 100 Waihuan Xi road, Education Mega Center, Guangzhou, 510006, China

Funder

Agence Nationale de la Recherche

Visiotact Pharma

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500784e

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1. The role of FAK in tumor metabolism and therapy

2. Disrupting the Scaffold to Improve Focal Adhesion Kinase–Targeted Cancer Therapeutics