1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity
Author:
Affiliation:
1. Centre for Chemical Biology
2. Chemistry
3. School of Environmental and Life Sciences
4. The University of Newcastle
5. Callaghan
6. Children's Medical Research Institute
7. The University of Sydney
8. Westmead NSW 2145
9. Australia
Abstract
Fragment-basedin silicoscreening against dynamin I (dynI) GTPase activity identified the 1,8-naphthalimide framework as a potential scaffold for the design of new inhibitors targeting the GTP binding pocket of dynI.
Funder
Australian Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00751H
Reference46 articles.
1. Dynamin, a membrane-remodelling GTPase
2. A Missense Mutation in a Highly Conserved Alternate Exon of Dynamin-1 Causes Epilepsy in Fitful Mice
3. Insights into the novel three ‘D's of epilepsy treatment: drugs, delivery systems and devices
4. Agonist-dependent Endocytosis of γ-Aminobutyric Acid Type A (GABAA) Receptors Revealed by a γ2(R43Q) Epilepsy Mutation
5. Osteoblast differentiation and migration are regulated by dynamin GTPase activity
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