The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models-Reference-Cited by-同舟云学术

The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models

Published:2023 Issue:8 Volume:14 Page:1492-1511
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Odell Luke R.¹^ORCID,Jones Nigel C.²³⁴,Chau Ngoc⁵,Robertson Mark J.¹,Ambrus Joseph I.¹,Deane Fiona M.¹,Young Kelly A.¹,Whiting Ainslie⁵,Xue Jing⁵,Prichard Kate¹,Daniel James A.⁵,Gorgani Nick N.⁵^ORCID,O'Brien Terence J.³⁴,Robinson Phillip J.⁵,McCluskey Adam¹^ORCID

Affiliation:

1. Chemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia

2. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia

3. Department of Neurology, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia

4. Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Parkville, Victoria 3052, Australia

5. Cell Signaling Unit, Children's Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia

Abstract

Modification of the known clathrin mediated endocytosis inhibitor dansylcadaverine to the sulfonadyns, dynamin GTPase inhibitors active in the 6 Hz psychomotor animal model of seizures.

Funder

Australian Cancer Research Foundation

National Health and Medical Research Council

Ramaciotti Foundations

Australian Research Council

Children’s Medical Research Institute

University of Newcastle Australia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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