Key factors in the discovery and development of new antiepileptic drugs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2997.pdf
Reference129 articles.
1. Bialer, M. et al. Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII). Epilepsy Res. 73, 1–52 (2007).
2. Bialer, M. et al. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 83, 1–43 (2009). An extensive summary of the preclinical pharmacology and clinical development of anticonvulsant drugs in development.
3. Bialer, M. New antiepileptic drugs (AEDs) in clinical development which are second generation to existing AEDs. Expert Opin. Invest. Drug. 15, 637–647 (2006). This review shows that the second-generation approach is quite popular in the development of new AEDs.
4. Callaghan, B. C., Anand, K., Hesdorffer, D., Hauser, W. A. & French, J. A. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann. Neurol. 62, 382–289 (2007).
5. Luciano, A. L. & Shorvon, S. D. Results of treatment changes in patientswith apparently drug-resistant chronic epilepsy. Ann. Neurol., 62, 375–381 (2007).
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