Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer-Reference-Cited by-同舟云学术

Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer

Published:2023 Issue:11 Volume:14 Page:2246-2267
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sun Jufeng¹²,Baker Jennifer R.¹^ORCID,Russell Cecilia C.¹,Pham Hong N. T.³^ORCID,Goldsmith Chloe D.³,Cossar Peter J.¹,Sakoff Jennette A.³,Scarlett Christopher J.⁴,McCluskey Adam¹^ORCID

Affiliation:

1. Chemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia

2. Medicinal Chemistry, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China

3. Experimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street, Waratah, NSW 2298, Australia

4. School of Environmental & Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, Australia

Abstract

Tight binding in the S100A2–p53 interaction groove = sub micromolar potencies against pancreatic cancer cell lines.

Funder

University of Newcastle Australia

Australian Cancer Research Foundation

Ramaciotti Foundations

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00289B

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