Functional characterization of a <i>C</i>-glycosyltransferase from <i>Pueraria lobata</i> with dual-substrate selectivity-Reference-Cited by-同舟云学术

Functional characterization of a C-glycosyltransferase from Pueraria lobata with dual-substrate selectivity

Published:2022 Issue:88 Volume:58 Page:12337-12340
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bao Yang-Oujie¹^ORCID,Zhang Meng¹,Qiao Xue¹^ORCID,Ye Min¹²^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China

2. Yunnan Baiyao International Medical Research Center, Peking University, 38 Xueyuan Road, Beijing 100191, China

Abstract

We reported a C-glycosyltransferase PlCGT with dual-substrate selectivity. An Asn16–Asp124 dyad may mediate the SN2-like mechanism in the C-glycosylation.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Peking University Health Science Center

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC04279G

Reference27 articles.

1. Advances in plant-derived C-glycosides: Phytochemistry, bioactivities, and biotechnological production

2. Advances in C-glycosylflavonoid Research

3. Neoglycorandomization and Chemoenzymatic Glycorandomization: Two Complementary Tools for Natural Product Diversification

4. Efficient Production of Orientin and Vitexin from Luteolin and Apigenin Using Coupled Catalysis of Glycosyltransferase and Sucrose Synthase

5. Production of isoorientin and isovitexin from luteolin and apigenin using coupled catalysis of glycosyltransferase and sucrose synthase

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