Author:
Li Changfu,Zhang Yansheng
Abstract
The pathway for forming isoflavonoid skeletal structure is primarily restricted to the Leguminosae family. Subsequent decorations on the compound backbone by tailoring enzymes would change their biological and medicinal properties. Pueraria lobata is a leguminous plant, and as a traditional Chinese medicine its roots have been ascribed a number of pharmacological activities. Glycosylation and methylation are the main modifying processes in isoflavonoid metabolism in P. lobata roots, resulting in the accumulation of unique glycosylated and methylated end isoflavonoid compounds. For instance, daidzein 8-C-glucoside (i.e., puerarin) and puerarin derivatives are produced only by the Pueraria genus. Puerarin has been established as a clinical drug for curing cardiovascular diseases. To better understand the characteristic isoflavonoid metabolism in P. lobata, this review attempts to summarize the research progress made with understanding the main glycosylation and methylation of isoflavonoids in P. lobata and their biosynthetic enzymes.
Reference57 articles.
1. Evaluation of pathways to the-glycosyl isoflavone puerarin in roots of kudzu (Pueraria montana lobata);Adolfo;Plant Direct,2022
2. Molecular mechanisms of anticancer activities of Puerarin;Ahmad;Cancer Manage. Res.,2020
3. New scheme of the biosynthesis of formononetin involving 2,7,4’-trihydroxyisoflavanone but not daidzein as the methyl acceptor;Akashi;Biosci. Biotechnol. Biochem.,2000
4. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4’-trihydroxyisoflavanone 4’-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway;Akashi;Plant Cell Physiol.,2003
5. Functional characterization of a C-glycosyltransferase from Pueraria lobata with dual-substrate selectivity;Bao;Chem. Commun.,2022
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献