Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu+ supplants entropically favoured Zn2+ to form Cu4+ clusters under physiological conditions-Reference-Cited by-同舟云学术

Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu⁺ supplants entropically favoured Zn²⁺ to form Cu₄⁺ clusters under physiological conditions

Published:2022 Issue:18 Volume:13 Page:5289-5304
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mehlenbacher Matthew R.¹,Elsiesy Rahma²,Lakha Rabina²,Villones Rhiza Lyne E.³,Orman Marina²,Vizcarra Christina L.²,Meloni Gabriele³^ORCID,Wilcox Dean E.¹^ORCID,Austin Rachel N.²^ORCID

Affiliation:

1. Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA

2. Department of Chemistry, Barnard College of Columbia University, New York, NY 10027, USA

3. Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080, USA

Abstract

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in metal homeostasis and detoxification.

Funder

National Institutes of Health

Welch Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00676F

Reference120 articles.

1. Advances in the structure and chemistry of metallothioneins

2. State-of-the-art of metallothioneins at the beginning of the 21st century

3. H.-J.Hartmann and U.Weser , Metallothioneins , in Biological Inorganic Chemistry , ed. I. Bertini , H. B. Gray , E. I. Stiefel , and J. S. Valentine , University Science Books , Sausalito , 2007 , pp. 156–174

4. The Functions of Metamorphic Metallothioneins in Zinc and Copper Metabolism

5. Three-dimensional solution structure of mouse [Cd7]-metallothionein-l by homonuclear and heteronuclear NMR spectroscopy

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Combining Native Mass Spectrometry and Proteomics to Differentiate and Map the Metalloform Landscape in Metallothioneins;Journal of Proteome Research;2024-07-12

2. Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis;Human Cell;2024-03-28

3. The effect of lipid metabolism on cuproptosis-inducing cancer therapy;Biomedicine & Pharmacotherapy;2024-03

4. A Peptoid-Chelator Selective to Cu2+ That Can Extract Copper from Metallothionein-2 and Lead to the Production of ROS;Antioxidants;2023-11-22

5. Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn;Metallomics;2023-10