Synthesis of 1,3,4-oxadiazoles as promising anticoagulant agents-Reference-Cited by-同舟云学术

Synthesis of 1,3,4-oxadiazoles as promising anticoagulant agents

Published:2016 Issue:29 Volume:6 Page:24797-24807
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

B. Iyer Vishwanathan¹²³⁴⁵,B. M. Gurupadayya¹²³⁴⁵,Inturi Bharathkumar¹²³⁴⁵,Sairam K. Venkata¹²³⁴⁵,Pujar Gurubasavaraj V.¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutical Chemistry

2. JSS College of Pharmacy

3. JSS University

4. Mysuru

5. India

Abstract

A series of 1,3,4-oxadiazoles were designed and subjected to molecular docking simulation onto the enzymes vitamin K epoxide reductase (PDB: 3KP9) and factor Xa (PDB: 1NFY) to visualize their binding affinity towards the said target proteins.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA01158F

Reference19 articles.

1. Thrombolytic Treatment of Acute Ischemic Stroke

2. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

3. Anticoagulant potential of regioselective derivatized cellulose

4. Assembly of the Warfarin-sensitive Vitamin K 2,3-Epoxide Reductase Enzyme Complex in the Endoplasmic Reticulum Membrane

5. Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range

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