Design, Synthesis, Anticancer Activity and Molecular Docking Studies of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Benzimidazole Moiety-Reference-Cited by-同舟云学术

Design, Synthesis, Anticancer Activity and Molecular Docking Studies of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Benzimidazole Moiety

Published:2020-12-08 Issue:12 Volume:17 Page:959-968
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Katikireddy Ramamurthy¹,Kakkerla Ramu²^ORCID,Krishna M.P.S. Murali³,Durgaiah Gandamalla⁴,Reddy Y.N.⁴

Affiliation:

1. Department of Chemistry, JNTUK, Kakinda, Andhra Pradesh- 533003, India

2. Department of Chemistry, Satavahana University, Karimnagar, Telangana State-505001, India

3. Department of Chemistry, Andhra Polytechnic College, Kakinada, Andhra Pradesh- 533003, India

4. Department of Pharmacology and Toxicology, Kakatiya University, Warangal, Telangana State- 506009, India

Abstract

A series of benzimidazolyl-1,3,4-oxadiazoles (7a-k) were synthesized and evaluated for in vitro anticancer activity against HeLa, MCF7, A549, and HEK293 cell lines. The results indicate that compounds 7b, 7j and 7k have shown excellent anticancer activity and while most of the compounds were non toxic to normal HEK293 cell lines. Molecular docking results of the synthesized compounds with the target Pin1 protein were also discussed.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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