Induced cytotoxicity of peptides by intracellular native chemical ligation-Reference-Cited by-同舟云学术

Induced cytotoxicity of peptides by intracellular native chemical ligation

Published:2022 Issue:32 Volume:46 Page:15551-15556
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Lee Jeonghun¹^ORCID,Oh Eun-Taex²,Lee Eunkyung¹,Park Heon Joo³,Kim Chulhee¹^ORCID

Affiliation:

1. Department of Polymer Science and Engineering, Program in Environmental and Polymer Engineering, Inha University, Incheon, 22212, Korea

2. Department of Biomedical Sciences, School of Medicine, Inha University, Incheon, 22212, Korea

3. Department of Microbiology, Hypoxia-related Disease Research Center, College of Medicine, Inha University, Incheon, 22212, Korea

Abstract

The intracellular NCL reaction of peptide with both N-terminal cysteine and C-terminal crypto-thioester with protecting groups occurs naturally in cancer cells, which endows peptide with induced cytotoxicity.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ02053J

Reference41 articles.

1. Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

2. Native chemical ligation in protein synthesis and semi-synthesis

3. Ligation Technologies for the Synthesis of Cyclic Peptides

4. Selective N-terminal modification of peptides and proteins: Recent progresses and applications

5. Synthesis of Proteins by Native Chemical Ligation

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1. Development and Applications of Ligation-Desulfurization-Desulfurization Strategy in Protein Chemical Synthesis;CHEM J CHINESE U;2024

2. Induced cytotoxicity of peptides with crypto-thioester through native chemical ligation;New Journal of Chemistry;2023