Induced cytotoxicity of peptides with crypto-thioester through native chemical ligation-Reference-Cited by-同舟云学术

Induced cytotoxicity of peptides with crypto-thioester through native chemical ligation

Published:2023 Issue:8 Volume:47 Page:3864-3869
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Lee Jeonghun¹^ORCID,Oh Eun-Taex²,Kim Jinhyeok¹,Kim Kitae¹,Park Heon Joo³,Kim Chulhee¹^ORCID

Affiliation:

1. Department of Polymer Science and Engineering, Program in Environmental and Polymer Engineering, Inha University, Incheon 22212, Korea

2. Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22212, Korea

3. Department of Microbiology, Research Center for Controlling Intracellular Communication, Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Korea

Abstract

For induced cytotoxicity, peptide fragments with low cytotoxicity were prepared, which can be coupled to form cytotoxic KLA peptide derivatives through native chemical ligation in reducing environments.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ05037D

Reference30 articles.

1. Selective N-terminal modification of peptides and proteins: Recent progresses and applications

2. Ligation Technologies for the Synthesis of Cyclic Peptides

3. Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

4. Native chemical ligation in protein synthesis and semi-synthesis

5. Synthesis of Proteins by Native Chemical Ligation

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