Transition-metal-free decarbonylative alkylation towards N-aryl α-hydroxy amides via triple C–C bond cleavages and their selective deuteration-Reference-Cited by-同舟云学术

Transition-metal-free decarbonylative alkylation towards N-aryl α-hydroxy amides via triple C–C bond cleavages and their selective deuteration

Published:2021 Issue:17 Volume:8 Page:4814-4819
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Sun Chengyu¹,Yu Yang¹,Zhang Xiao¹,Liu Yonghai¹,Sun Chengtao²,Kai Guoyin²,Shi Lei³,Li Hao¹^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

2. Laboratory of Medicinal Plant Biotechnology, College of pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China

3. Huabao Flavours & Fragrances Co., Ltd., 1299 Yecheng Road, Shanghai 201822, China

Abstract

A transition-metal-free decarbonylative alkylation reaction for the synthesis of N-aryl α-hydroxy amides via precise cleavages and reorganizations of three C–C σ bonds has been developed.

Funder

Higher Education Discipline Innovation Project

Zhejiang Chinese Medical University

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO00530H

Reference69 articles.

1. Recent Advances in Transition-Metal-Catalyzed Functionalization of Unstrained Carbon–Carbon Bonds