From intramolecular cyclization to intermolecular hydrolysis: TMSCF<sub>2</sub>Br-enabled carbonylation of aldehydes/ketones and amines to α-hydroxyamides-Reference-Cited by-同舟云学术

From intramolecular cyclization to intermolecular hydrolysis: TMSCF₂Br-enabled carbonylation of aldehydes/ketones and amines to α-hydroxyamides

Published:2023 Issue:21 Volume:10 Page:5343-5351
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu An¹,Sun Shuo¹,Xie Qiqiang¹,Huang Rumin¹,Kong Taige¹,Ni Chuanfa¹,Hu Jinbo¹^ORCID

Affiliation:

1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China

Abstract

An unprecedented metal-free multicomponent reaction enables rapid and straightforward access to structurally diverse α-hydroxyamides from carbonyl compounds (aldehydes/ketones), difluorocarbene and amines.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00665D

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3. α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists

4. Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism

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