Electrochemical α-deuteration of amides-Reference-Cited by-同舟云学术

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Electrochemical α-deuteration of amides

Published:2023 Issue:23 Volume:25 Page:9993-9997
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Ning Shulin¹,Wu Cheng¹,Zheng Lianyou¹^ORCID,Liu Mian¹,Zhang Yan¹,Che Xin¹,Xiang Jinbao¹²^ORCID

Affiliation:

1. The Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R. China

2. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, Jilin 130021, P. R. China

Abstract

An efficient electroselective α-deuteration of amides was realized via H–D exchange under mild neutral conditions. Its utility has been well exemplified in the late-stage modification of drug molecules and transformation to β-bisdeuterated amines.

Funder

National Natural Science Foundation of China

Jilin University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC02345A

Reference35 articles.

1. Deuterium in drug discovery: progress, opportunities and challenges

2. First deuterated drug approved

3. Donafenib: First Approval

4. Deucravacitinib: First Approval

5. VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19

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1. Green and efficient choline hydroxide-promoted C(sp3)-H selenation of arylacetamides at room temperature;Molecular Catalysis;2024-10

2. Copper-Catalyzed Borrowing Hydrogen Reaction for α-Alkylation of Amides with Alcohols;The Journal of Organic Chemistry;2024-06-20

3. Electrochemical selective deuterium labelling of N-heteroarenes;Green Synthesis and Catalysis;2024-06

4. Electrochemical γ-Selective Deuteration of Pyridines;Organic Letters;2024-05-16

5. Electroselective C(sp³)–H deuteration of isoindolinones;Organic Chemistry Frontiers;2023

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