Identification, isolation, structural characterization, in silico toxicity prediction and in vitro cytotoxicity assay of simeprevir acidic and oxidative degradation products-Reference-Cited by-同舟云学术

Identification, isolation, structural characterization, in silico toxicity prediction and in vitro cytotoxicity assay of simeprevir acidic and oxidative degradation products

Published:2020 Issue:70 Volume:10 Page:42816-42826
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ahmed Rasha M.¹²³⁴⁵,Fayed Marwa A. A.⁶²⁷⁸⁵^ORCID,El-Behairy Mohammed F.⁹²⁷⁸⁵^ORCID,Abdallah Inas A.¹⁰²⁷⁸⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Faculty of Pharmacy

3. Misr International University

4. Cairo 11341

5. Egypt

6. Department of Pharmacognosy

7. University of Sadat City

8. Sadat City 32897

9. Department of Organic and Medicinal Chemistry

10. Department of Analytical Chemistry

Abstract

Simeprevir is a new direct-acting antiviral drug used for the treatment of chronic hepatitis C.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA09253C

Reference42 articles.

1. FDA , Guidance for Industry, Chronic Hepatitis C virus infection: Developing direct – Acting antiviral drugs for treatment , 2017

2. New treatments for genotype 1 chronic hepatitis C – focus on simeprevir

3. Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

4. Sustained virological response to interferon plus ribavirin reduces liver-related complications and mortality in patients coinfected with human immunodeficiency virus and hepatitis C virus

5. Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Heliotropium ramosissimum metabolic profiling, in silico and in vitro evaluation with potent selective cytotoxicity against colorectal carcinoma;Scientific Reports;2022-07-22

2. The anti-COVID-19 drug Favipiravir: Degradation, Method development, Validation, NMR/LC–MS characterization, and In-vitro safety evaluation;Chemical Papers;2022-07-04

3. Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms;Molecules;2021-07-30